Study links PPIs to kidney failure in 125,000 patients

A February 2017 study by Kidney International found that Proton Pump Inhibitors (PPIs) may cause adverse effects on the human kidney. 
Previously thought of as a safe medication class, the study found that 125,000 individuals who used PPIs, suffered from kidney failure, despite previously not showing signs of this or other acute kidney problems before PPI use. 
PPIs include medications such as Nexium and Prevacid, which are highly prescribed, and individuals are cautioned to take more care when using these medications. Patients taking PPIs are advised to have regular check-ups with their physicians in order to be able to discern the presence of problems before they arise. 
The true danger of kidney failure is that the symptoms are often completely hidden until the damage of the failure has already taken place. 
PPIs also have been found to cause an increase to poor and extensive metabolizer phenotypes in genetic variations of CYP2C19.